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NR4A1 suppresses breast cancer growth by repressing c-Fos-mediated lipid and redox dyshomeostasis (RNA-seq)

GSE281571 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/18 Platform GPL20795
Summary
The precise function of NR4A1 as a transcriptional regulator in cancer remains under investigation. To investive the biological functions and molecular mechanims by which NR4A1 suppresses breast cancer growth, we perform RNA sequence analysis in NR4A1-knockout and control MCF7 cell lines to identify the alterated signaling pathway and celluar possesses in breast cancer. Besides, we also performed ChIP sequences by c-Fos ChIP in in NR4A1-knockout and control MCF7 cell lines to investigate the competitive function of NR4A1 on c-Fos binding to genome.
Published in
NR4A1 suppresses breast cancer growth by repressing c-Fos-mediated lipid and redox dyshomeostasis
Jiang C, Zhu Y, Zhang J et al. · Experimental & molecular medicine 2025 · PMID 40164686 · doi:10.1038/s12276-025-01430-3
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Also filed as BioProject PRJNA1184738 and SRA study SRP544518. Searching any of these in the dataset finder brings you back here.

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