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Human scRNA-seq of three primary and five metastatic breast cancers

GSE281580 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/03/27 Platform GPL24676
Summary
A key problem in cancer biology is understanding the phenotypic characteristics of the aggressive cell states present in macrometastases and their molecular underpinnings. Here we report on the cellular constituents of human breast cancer metastases, revealing that these malignant cells are invariably locked in a chimeric cell state. Human BC metastatic cells indeed display a gene-expression profile associated to embryonic development of tubular organs, while also retaining the transcriptional features of the primary tumor subtype.
Published in
A 3D morphogenetic blueprint for metastatic outgrowth in breast cancer
Caire R, Bordo R, Zanconato F et al. · Cell 2026 · PMID 41923644 · doi:10.1016/j.cell.2026.03.009
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Also filed as BioProject PRJNA1184758 and SRA study SRP544522. Searching any of these in the dataset finder brings you back here.

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