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Single-cell temporal characterization of RSV infection

GSE281623 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/04/16 Platform GPL25526
Summary
Respiratory syncytial virus (RSV) is a prevalent pathogen globally, can cause severe disease in older adults, and remains the leading cause of bronchiolitis and pneumonia in the United States for children during their first year of life. Despite its prevalence worldwide, RSV specific pharmacologic interventions remain unavailable for most infected patients. Although vaccines are available for a subset of adults, further investigation of the molecular interactions between RSV and the host remains essential to understanding this prolific pathogen. To aid our understanding of the host response in both RSV infected cells, and uninfected bystanders, we utilized single-cell RNA sequencing.
Published in
Defining the host dependencies and the transcriptional landscape of RSV infection and bystander activation
Sunshine S, Puschnik A, Retallack H et al. · bioRxiv : the preprint server for biology 2025 · PMID 40196489 · doi:10.1101/2025.03.26.645108
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Also filed as BioProject PRJNA1184817 and SRA study SRP544565. Searching any of these in the dataset finder brings you back here.

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