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ChIP-seq and RNA-seq analysis reveals the association between thyroid hormone receptor α and skeletal muscle aging in mice(ChIP-seq)

GSE281837 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/06/03 Platform GPL24247
Summary
In the current situation of the aging of the global population, primary sarcopenia is gradually attracting attention because of its potential risk to the elderly, high occult incidence and serious prognosis. As one of the most important hormones affecting skeletal muscle, the aging changes of thyroid hormone have been proved to be closely related to sarcopenia. Thyroid hormone exerts its effects locally in skeletal muscle by binding to thyroid hormone receptor. TRα is the main distribution type of thyroid hormone receptor in skeletal muscle. We have previously found the potential role of TRα in the aging process of skeletal muscle. As a nuclear transcription factor, TRα exerts subsequent biological effects by targeting regulatory genes. However, in the process of skeletal muscle aging, the target regulation map of TRα is still unclear.In this study, we constructed natural aging mouse models of different ages, combined ChIP-seq and mRNA-seq to explore the aging changes of TRα targets in skeletal muscle.
Published in
RNA-seq and ChIP-seq unveils thyroid hormone receptor α deficiency affects skeletal muscle myoblast proliferation and differentiation via Col6a1 during aging
Shi R, Chen G, Zhang Y et al. · Journal of muscle research and cell motility 2025 · PMID 40317420 · doi:10.1007/s10974-025-09694-y
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Direct links to NCBI, no account and no request form: the whole study as GSE281837_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1185790 and SRA study SRP545077. Searching any of these in the dataset finder brings you back here.

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