Anterior cingulate cortex mediates the comorbidity between colorectal cancer and depression-like behaviors
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 7 × Be vs 5 × BC vs 4 × NCGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Anterior cingulate cortex mediates the comorbidity between colorectal cancer and depression-like behaviorsCommunications biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281840_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1185799 and SRA study SRP545193. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 3 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8630831 NC1 NC
- GSM8630832 NC2 NC
- GSM8630833 NC3 NC
- GSM8630834 NC4 NC
- GSM8630835 BC2 BC
- GSM8630836 BC3 BC
- GSM8630837 BC4 BC
- GSM8630838 BC5 BC
- GSM8630839 BC6 BC
- GSM8630840 Be1 Be
- GSM8630841 Be2 Be
- GSM8630842 Be3 Be
- GSM8630843 Be4 Be
- GSM8630844 Be5 Be
- GSM8630845 Be6 Be
- GSM8630846 Be8 Be
- GSE241929 Hyperactive lateral habenula mediates the comorbidity between rheumatoid arthritis and depression-like behaviors 11 samples shares depression-like, comorbidity, behaviors, mediates
- GSE308643 A pathway from the anterior cingulate cortex to the lateral habenula controls chronic pain induced depression in male mice 22 samples shares cingulate, anterior, cortex
- GSE261723 3M-Brazzein, a Natural Sugar Substitute, can Suppress Metabolic Disorders, NAFLD, and Depression-like Behaviors in Diabetic Mice 24 samples shares depression-like, behaviors
- GSE275353 Exploring the Mechanism of SETDB1 in Regulating Neuroinflammation and Anxiety-Depression-like Behaviors [RNA-seq] 19 samples shares depression-like, behaviors
- GSE315740 Effects of Aerobic Exercise on Depression-Like Behaviors and Hippocampal Transcriptomics in CSDS-Induced Adolescent Mice 18 samples shares depression-like, behaviors
- GSE280084 A Multipotent PROX1+ Tumor Cell Population Emerges During Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer 13 samples shares colorectal, mediates
- GSE282497 NEDD4L mediates intestinal epithelial cell ferroptosis to restrict inflammatory bowel diseases and colorectal tumorigenesis 6 samples shares colorectal, mediates
- GSE223323 Enterocyte like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability 148 samples shares colorectal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.