A Multipotent PROX1+ Tumor Cell Population Emerges During Intestinal Tumorigenesis and Mediates Radioresistance in Colorectal Cancer
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 13 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280084_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1176173 and SRA study SRP540868. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 13 sample titles: 13 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8587191 ApcMin ctrl biol rep 1, scRNAseq
- GSM8587192 ApcMin ctrl biol rep 2, scRNAseq
- GSM8791772 ApcMin ctrl biol rep 3, scRNAseq
- GSM8791773 ApcMin ctrl biol rep 4, scRNAseq
- GSM8791774 ApcMin ctrl biol rep 5, scRNAseq
- GSM8791775 ApcMin 1d after 2 Gy IR biol rep 1, scRNAseq
- GSM8791776 ApcMin 1d after 2 Gy IR biol rep 2, scRNAseq
- GSM8791777 ApcMin 1d after 2 Gy IR biol rep 3, scRNAseq
- GSM8791778 ApcMin 2d after 2 Gy IR biol rep 1, scRNAseq
- GSM8791779 ApcMin 2d after 2 Gy IR biol rep 2, scRNAseq
- GSM8791780 ApcMin 7d after 2 Gy IR biol rep 1, scRNAseq
- GSM8791781 ApcMin 7d after 2 Gy IR biol rep 2, scRNAseq
- GSM8791782 Wild type biol rep 1, scRNAseq
- GSE282497 NEDD4L mediates intestinal epithelial cell ferroptosis to restrict inflammatory bowel diseases and colorectal tumorigenesis 6 samples shares tumorigenesis, intestinal, colorectal, mediates
- GSE224831 Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis [Prox1 OE iHep Timecourse RNA-seq] 16 samples shares prox1, tumorigenesis
- GSE224830 Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis [Prox1 OE iHep Timecourse scRNA-seq] 13 samples shares prox1, tumorigenesis
- GSE224825 Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis [Prox1 OE MEF/4in1 ATAC-seq] 12 samples shares prox1, tumorigenesis
- GSE272850 Polyclonal interactions overcome fitness barriers in Apc-driven intestinal tumorigenesis 63 samples shares tumorigenesis, intestinal
- GSE275908 CXCL12-CXCR4 signaling mediates the formation of a macrophageal niche for mammary gland development and tumorigenesis 30 samples shares tumorigenesis, mediates
- GSE306906 Fosl1 is a transcriptional effector of BRAFV600E-driven intestinal tumorigenesis 27 samples shares tumorigenesis, intestinal
- GSE269506 The interleukin 22–oncostatin M axis promotes intestinal inflammation and tumorigenesis [Colon_Tissue_BulkRNA-seq] 22 samples shares tumorigenesis, intestinal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.