← BioTransfer GEO Dataset Finder
GEO series

The effect of Zinc defficiency on the mouse paneth cell transcriptome in TNF context

GSE281875 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/26 Platform GPL34475
Summary
We investigated the effect of zinc depletion on the mouse intestine, and specifically on paneth cells. Mice were placed on a zinc depleted diet for 7 weeks after which they were given TNF for 3 hours and the the effects of dietary zinc shortage on paneth cells in TNF context were investigated. A zinc is an essential element for correct paneth cell function and zinc defficiency is a human and animal health problem investigating the PC transcriptom my provide valuable insights into the exact mechanism.
Published in
Detection of chimeric alpha-defensin transcripts and peptides in mouse Paneth cells
Timmermans S, Wallaeys C, De Beul S et al. · Frontiers in immunology 2025 · PMID 39981239 · doi:10.3389/fimmu.2025.1543059
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE281875_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1186093 and SRA study SRP545216. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.