GEO series
RNA-seq analysis of resistant ER+ breast cancer cell lines
GSE281935
Homo sapiens
Expression profiling by high throughput sequencing
21 samples
2025/04/16
GPL34284
Summary
This study aims to identify transcriptional differences between parental ER+ breast cancer cell lines and those that are resistant to several common endocrine therapies, including tamoxifen, fulvestrant, and aromatase inhibition. To mimic aromatase inhibitors, cells were grown in estrogen withdrawl (EWD) conditions, using phenol red free media and charcoal-stripped serum. Cells were kept in their respective treatments until RNA was procured.
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Paper (PMID 40055794) ↗
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