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Transcriptomic Profiling of Myeloid Cells in Acetaminophen-Induced Acute Liver Failure

GSE281951 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/01/13 Platform GPL34328
Summary
In the recent study, we found that mesenchymal stem cell (MSC)-derived extracellular vesicles expressing the SIRPα protein (SIRP-EVs) were significantly distributed within myeloid cells (CD11b+ cells) and kupffer cells (CD11b+/F4/80+ cells) in acetaminophen (APAP)-induced mouse acute liver failure (ALF) model. Furthermore, SIRP-EVs enhanced the phagocytic activity of macrophages by blocking CD47 on necroptotic hepatocytes and promoted liver regeneration. Therefore, we investigated the therapeutic effects of SIRP-EVs on CD11b+ cells in APAP-induced ALF conditions. CD11b+ cells in the liver, including resident and recruited CD11b+ cells, were harvested and analyzed through bulk RNA sequencing.
Published in
Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure
Kim S, Kim YK, Kim S et al. · Nature communications 2025 · PMID 39988725 · doi:10.1038/s41467-025-57133-w
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Also filed as BioProject PRJNA1186238 and SRA study SRP545321. Searching any of these in the dataset finder brings you back here.

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