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In vivo model of progressive tumor development in the anorectal transition zone (TZ)

GSE281986 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2025/10/20 Platform GPL19057
Summary
Epithelial junctions are areas of associated pathology in human and mouse. In the case of the anorectal junction there is an abrupt transition from a simple columnar to a stratified squamous epithelium. To identify new regulatory mechanisms during injury and tumorigenesis, we studied this so called anorectal transition zone (TZ) at the single cell level. To this end, we took advantage of a mouse injury model where TZ cells are traced with fluorescent kerating 17 (K17CreER T2 x LSL-EGFP) at different points during transformation.
Published in
Injury and inflammation promote cancer progression at the anorectal junction
Petitpas C, Mitoyan L, Thevin V et al. · Cell reports 2025 · PMID 41236926 · doi:10.1016/j.celrep.2025.116552
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Also filed as BioProject PRJNA1186568 and SRA study SRP545432. Searching any of these in the dataset finder brings you back here.

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