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Expression Analysis between HUVECs and EndMTed HUVECs

GSE281995 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/28 Platform GPL24676
Summary
Prostate cancer often progresses to castration-resistant prostate cancer (CRPC), with neuroendocrine prostate cancer (NEPC) representing a highly aggressive variant. This study shows that endothelial-to-mesenchymal transition (EndMT) in vascular endothelial cells, induced by IL-1β and TGF-β2, enhances neuroendocrine differentiation in prostate cancer cells. LNCaP cells co-cultured with EndMTed HUVECs exhibited increased expression of neuroendocrine markers such as chromogranin A. GM-CSF emerged as a key mediator in this process, and its addition under androgen deprivation conditions further elevated neuroendocrine marker expression. Anti-androgen therapy with enzalutamide also paradoxically increased IL-1β and TGF-β2 secretion, promoting EndMT and subsequent neuroendocrine differentiation. These results highlight the potential of targeting EndMT and GM-CSF pathways as therapeutic strategies for aggressive, treatment-resistant forms of NEPC.
Published in
Endothelial-Mesenchymal Transition in Tumor Microenvironment Promotes Neuroendocrine Differentiation of Prostate Cancer
Kageyama T, Kato M, Miyachi S et al. · Cancer science 2025 · PMID 40706636 · doi:10.1111/cas.70144
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Also filed as BioProject PRJNA1181033 and SRA study SRP542692. Searching any of these in the dataset finder brings you back here.

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