RNA-seq analysis of human monocytes in patients with and without coronary atherosclerosis
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 11 × w.o. CA monocytes vs 9 × w. CA monocytesGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Impaired LPS tolerance in monocytes of coronary atherosclerosis patients is associated with the intermediate subsetJournal of leukocyte biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282042_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1186704 and SRA study SRP545488. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 2 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8634820 w. CA monocytes1 w. CA monocytes
- GSM8634821 w. CA monocytes2 w. CA monocytes
- GSM8634822 w. CA monocytes3 w. CA monocytes
- GSM8634823 w. CA monocytes4 w. CA monocytes
- GSM8634824 w. CA monocytes5 w. CA monocytes
- GSM8634825 w. CA monocytes6 w. CA monocytes
- GSM8634826 w. CA monocytes7 w. CA monocytes
- GSM8634827 w. CA monocytes8 w. CA monocytes
- GSM8634828 w. CA monocytes9 w. CA monocytes
- GSM8634829 w.o. CA monocytes1 w.o. CA monocytes
- GSM8634830 w.o. CA monocytes2 w.o. CA monocytes
- GSM8634831 w.o. CA monocytes3 w.o. CA monocytes
- GSM8634832 w.o. CA monocytes4 w.o. CA monocytes
- GSM8634833 w.o. CA monocytes5 w.o. CA monocytes
- GSM8634834 w.o. CA monocytes6 w.o. CA monocytes
- GSM8634835 w.o. CA monocytes7 w.o. CA monocytes
- GSM8634836 w.o. CA monocytes8 w.o. CA monocytes
- GSM8634837 w.o. CA monocytes9 w.o. CA monocytes
- GSM8634838 w.o. CA monocytes10 w.o. CA monocytes
- GSM8634839 w.o. CA monocytes11 w.o. CA monocytes
- GSE237489 RNA-seq for iPSC-derived macrophages with/without Lipopolysaccharide (LPS) stimulation. 8 samples shares rna-seq, without
- GSE205672 Transcriptomes of human PBMCs and monocytes in sepsis patients 460 samples shares monocytes
- GSE292858 RNA-Seq analysis of tumor and matched normal samples from colorectal cancer patients. 73 samples shares rna-seq
- GSE319641 RNA-Seq profiling of pre- and on-treatment tumor samples from breast cancer patients enrolled in the NeoTRIP trial. 401 samples shares rna-seq
- GSE227835 Single-cell RNA-seq data of human PBMC from Myasthenia Gravis patients 40 samples shares rna-seq
- GSE309595 Longitudinal Analysis of Multiple Myeloma: Therapeutic Response and Immune Microenvironment Dynamics in the Context of Tumor Heterogeneity [scRNA-seq] 270 samples shares rna-seq
- GSE297742 Bulk RNA-seq of primary tumor biopsy samples from prostate adenocarcinoma patients 234 samples shares rna-seq
- GSE327707 Sorted bulk RNA-seq profiling of human peripheral blood mononuclear cell populations across diverse in vitro immune stimuli 150 samples shares rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.