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Gene expression profile of the HOXA gene in adult dermal fibroblasts

GSE282261 Homo sapiens (human) RNA-seq (gene expression) 3 samples Submitted 2025/04/13 Platform GPL24676
At a glance

RNA-seq (gene expression) · human · 3 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
3 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Site-Specific Expression of HOXA Genes in Skin and its Effect on Skin ElasticityThe Journal of investigative dermatology · 2025
Summary (written by the submitters)
The skin is the largest organ covering the entire body, composed of three layers: the epidermis, dermis, and subcutaneous tissue. While the thickness and elasticity of the skin are known to vary depending on the body site, the mechanisms underlying these differences remain unclear. Recent studies have reported that HOX genes, which determine positional identity during development, are also expressed and functional in adult tissues.
Read the full summary ↓
We found that the expression of HOXA cluster genes in dermal fibroblasts derived from adult skin is regulated in a site-specific manner. Inhibition of HOXA9 expression in adult dermal fibroblasts resulted in decreased cell proliferation and downregulation of extracellular matrix-related genes. These findings suggest that the positional memory established by HOX genes during development is maintained in adults, contributing to the homeostasis and regional differences observed in adult skin.
Published in
Site-Specific Expression of HOXA Genes in Skin and its Effect on Skin Elasticity
Okuno R, Hasegawa S, Hasebe Y et al. · The Journal of investigative dermatology 2025 · PMID 40268230 · doi:10.1016/j.jid.2025.04.005
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282261_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1188005 and SRA study SRP546119. Searching any of these in the dataset finder brings you back here.

Samples in this study

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