Heterologous immunization combining vector- and mRNA-based vaccine elicits both robust innate and adaptive immune responses
Single-cell RNA-seq · mouse · 3 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 3 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Heterologous prime-boost vaccination drives stromal activation and adaptive immunity against SARS-CoV-2 variantsFrontiers in immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282488_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1189001 and SRA study SRP546671. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 3 more — browse all 3 samples with per-sample file links →
- GSE292434 Heterologous Prime-Boost Immunization of AAV-based Neoantigen Cancer Vaccine Induces Anti-Tumor Immunity to Inhibit Tumor Growth and Relapse 12 samples shares heterologous, immunization, vaccine
- GSE288450 Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell clonal diversity and clonal expansion 33 samples shares combining, vaccine
- GSE255778 Glycan adjuvantation expands the breadth and duration of protection of a mRNA-based vaccine 30 samples shares mrna-based, vaccine
- GSE306862 Synthetic DNA co-immunization with vaccine-aligned common consensus nucleoprotein and hemagglutinin protects mice against lethal influenza infection with a single immunization 20 samples shares immunization, vaccine
- GSE264141 RNA signatures followed by immunization of multiantigenic adenovirus-based vaccine candidate against mycobacterium tuberculosis 18 samples shares immunization, vaccine
- GSE280660 Transcriptional analysis of blood-borne immune cells induced by VSV-based vaccines: A comparison before and after immunization 18 samples shares immunization, vaccine
- GSE315320 A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines. 12 samples shares mrna-based, vaccine
- GSE248086 Staggered immunization with mRNA vaccines encoding SARS-CoV-2 polymerase or spike antigens broadens the T cell epitope repertoire 2 samples shares immunization, vaccine
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.