Aberrant Neuronal Connectivity and Network Activity of Neurons Derived from Patients with Idiopathic Schizophrenia
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 4 × AD2 Neurons, SZ, vs 4 × AD2, SZ, vs 3 × AD2 Neurons, Control, vs 3 × hNGN2 Neurons, Control,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Aberrant neuronal connectivity and network activity of neurons derived from patients with idiopathic schizophreniaNeurobiology of disease · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282524_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1189093 and SRA study SRP546799. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8645507 AD2 Neurons, Control, Replicate1 AD2 Neurons, Control,
- GSM8645508 AD2 Neurons, Control, Replicate2 AD2 Neurons, Control,
- GSM8645509 AD2 Neurons, Control, Replicate3 AD2 Neurons, Control,
- GSM8645510 AD2 Neurons, SZ, Replicate1 AD2 Neurons, SZ,
- GSM8645511 AD2 Neurons, SZ, Replicate2 AD2 Neurons, SZ,
- GSM8645512 AD2 Neurons, SZ, Replicate3 AD2 Neurons, SZ,
- GSM8645513 AD2 Neurons, SZ, Replicate4 AD2 Neurons, SZ,
- GSM8645514 hNGN2 Neurons, Control, Replicate1 hNGN2 Neurons, Control,
- GSM8645515 hNGN2 Neurons, Control, Replicate2 hNGN2 Neurons, Control,
- GSM8645516 hNGN2 Neurons, Control, Replicate3 hNGN2 Neurons, Control,
- GSM8645517 AD2, SZ, Replicate1 AD2, SZ,
- GSM8645518 AD2, SZ, Replicate2 AD2, SZ,
- GSM8645519 AD2, SZ, Replicate3 AD2, SZ,
- GSM8645520 AD2, SZ, Replicate4 AD2, SZ,
- GSE301134 Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na+ channel dynamics in human neurons 53 samples shares schizophrenia, neuronal, network, neurons
- GSE304368 Schizophrenia risk gene ZNF536 modulates retinoic acid response and neuronal gene networks in SH-SY5Y cells 18 samples shares schizophrenia, neuronal, network
- GSE311978 Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia. [RNA-Seq] 97 samples shares schizophrenia, neurons
- GSE305464 Pre-clinical proof-of-concept of anti-fibrotic activity of caveolin-1 scaffolding domain peptide LTI-03 in ex vivo precision cut lung slices from patients with Idiopathic Pulmonary Fibrosis 94 samples shares idiopathic, activity
- GSE278808 Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons 26 samples shares schizophrenia, neurons
- GSE293155 SETD1A Regulates Psychiatric Gene Networks Involved in Genomic Stability and Synaptic Function in Rare and Sporadic Schizophrenia [bulk RNA-seq] 24 samples shares schizophrenia, network
- GSE244005 Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome and schizophrenia. [scRNA-Seq] 12 samples shares schizophrenia, aberrant
- GSE250482 Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects. 10 samples shares schizophrenia, neurons
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.