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Effect of miR-4800-3p overexpression on gene expression related to metastasis in pancreatic cancer cell lines (MIA PaCa-2 and PSN-1)

GSE282572 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/06/18 Platform GPL24676
Summary
Understanding the molecular characteristics of pancreatic cancer liver metastases is essential for advancing individualized treatment strategies. This study identifies miR-4800-3p as a potential contributor to liver metastasis. miR-4800-3p appears to promote liver metastasis by directly targeting PLAA, inhibiting ubiquitination, and stabilizing METTL3 protein. This process enhances the expression of the oncogene GPRC5A, potentially driving metastatic progression.
Published in
Exosomal microRNA-4800-3p in portal vein blood promotes liver metastasis in pancreatic cancer by targeting PLAA
Miyahara S, Takahashi H, Tomimaru Y et al. · Scientific reports 2026 · PMID 42002588 · doi:10.1038/s41598-026-48779-7
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Also filed as BioProject PRJNA1189157 and SRA study SRP546846. Searching any of these in the dataset finder brings you back here.

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