Sex-Specific Astrocyte Regulation of Spinal Motor Circuits by Nkx6.1 [RNA-seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × male mouse spinal cord tissue, Nkx6.1 Control, GFP astrocytes, vs 3 × male mouse spinal cord tissue, Nkx6.1 cKO, GFP astrocytes, vs 3 × female mouse spinal cord tissue, Nkx6.1 Control, GFP astrocytes, vs 3 × female mouse spinal cord tissue, Nkx6.1 cKO, GFP astrocytes,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282689_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1189799 and SRA study SRP547149. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8648841 male mouse spinal cord tissue, Nkx6.1 Control, GFP astrocytes, replicate1 male mouse spinal cord …
- GSM8648842 male mouse spinal cord tissue, Nkx6.1 Control, GFP astrocytes, replicate2 male mouse spinal cord …
- GSM8648843 male mouse spinal cord tissue, Nkx6.1 Control, GFP astrocytes, replicate3 male mouse spinal cord …
- GSM8648844 male mouse spinal cord tissue, Nkx6.1 cKO, GFP astrocytes, replicate1 male mouse spinal cord …
- GSM8648845 male mouse spinal cord tissue, Nkx6.1 cKO, GFP astrocytes, replicate2 male mouse spinal cord …
- GSM8648846 male mouse spinal cord tissue, Nkx6.1 cKO, GFP astrocytes, replicate3 male mouse spinal cord …
- GSM8648847 female mouse spinal cord tissue, Nkx6.1 Control, GFP astrocytes, replicate 1 female mouse spinal cor…
- GSM8648848 female mouse spinal cord tissue, Nkx6.1 Control, GFP astrocytes, replicate 2 female mouse spinal cor…
- GSM8648849 female mouse spinal cord tissue, Nkx6.1 Control, GFP astrocytes, replicate 3 female mouse spinal cor…
- GSM8648850 female mouse spinal cord tissue, Nkx6.1 cKO, GFP astrocytes, replicate 1 female mouse spinal cor…
- GSM8648851 female mouse spinal cord tissue, Nkx6.1 cKO, GFP astrocytes, replicate 2 female mouse spinal cor…
- GSM8648852 female mouse spinal cord tissue, Nkx6.1 cKO, GFP astrocytes, replicate 3 female mouse spinal cor…
- GSE99058 Single cell RNA-seq of mouse brain astrocyte transcriptomes 250 samples shares astrocyte, rna-seq
- GSE263738 Bi-directional immunosuppressive interactions between astrocytes and glioblastoma cells identified by barcoded viral tracing [Mouse Bulk RNA-Seq Dataset of Monocytes, T Cells and Astrocytes 63FG] 57 samples shares astrocyte, rna-seq
- GSE316703 Microbiota-Derived Isovalerate Ameliorates Sex-Specific Gut Barrier Dysfunction in Malnutrition [RNA-seq colon epithelium] 50 samples shares sex-specific, rna-seq
- GSE306262 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [RNA-seq] 40 samples shares astrocyte, rna-seq
- GSE287234 Intrauterine hyperglycemia impairs primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference in mice offspring [RNA-seq] 36 samples shares sex-specific, rna-seq
- GSE263737 Bi-directional immunosuppressive interactions between astrocytes and glioblastoma cells identified by barcoded viral tracing [Mouse Bulk RNA-Seq Dataset of Monocytes, T Cells and Astrocytes 5OLJ] 33 samples shares astrocyte, rna-seq
- GSE304112 Establishment of sex-specific liver transcriptomes and H3K9me3 profiles during sexual maturity: the impact of maternal obesity [RNA-seq] 32 samples shares sex-specific, rna-seq
- GSE240857 Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner[RNA-Seq] 29 samples shares astrocyte, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.