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Impact of TAZ (WWTR1) depletion on gene expression during primary first-trimester extravillous trophoblast differentiation

GSE282830 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/28 Platform GPL18573
Summary
Human placental cytotrophoblasts undergo differentiation into extravillous trophoblasts (EVTs) that anchor the placenta to the uterine wall and establish blood flow to the developing fetus. The transcriptional co-activator TAZ (WWTR1) is one of the main effectors of the Hippo signaling pathway, which regulates organ size by controlling important cellular processes such as cell proliferation, apoptosis, stem cell self-renewal and differentiation. Additionally, TAZ is involved in mechano-sensing and cell contact inhibition. In order to gain deeper insights into the function of TAZ in the EVT differentiation process, siRNA (small interfering RNA) treatment was employed to reduce TAZ levels in cytotrophoblasts, which were collected from placentae between 8th and 10th weeks of pregnancy, and underwent EVT differentiation in vitro. The objective of the study was to elucidate the influence of TAZ on the differentiation and function of EVTs by comparing the gene expression profiles of TAZ gene-silenced cells to those with normal TAZ levels.
Published in
The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta
Meinhardt G, Waldhäusl H, Lackner AI et al. · Proceedings of the National Academy of Sciences of the United States of America 2025 · PMID 40228123 · doi:10.1073/pnas.2426385122
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Also filed as BioProject PRJNA1190489 and SRA study SRP547544. Searching any of these in the dataset finder brings you back here.

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