microRNA-497-5p-based Screening Identifies a Novel Synthetic Lethal-type Interaction via PKMYT1 and WEE1 in Pleural Mesothelioma
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- MesotheliomaThis series is part of our curated briefing on it.
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- microRNA-497-5p-based screening identifies a novel synthetic lethal-type interaction via PKMYT1 and WEE1 in pleural mesotheliomaMolecular therapy. Nucleic acids · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282870_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1190910 and SRA study SRP547699. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8651782 RNA-seq at 12 hours with Control miRNA, Rep 1 RNA-seq at 12 hours wit…
- GSM8651783 Pull-down at 12 hours with Control miRNA, Rep 1 Pull-down at 12 hours w…
- GSM8651784 RNA-seq at 12 hours with Control miRNA, Rep 2 RNA-seq at 12 hours wit…
- GSM8651785 Pull-down at 12 hours with Control miRNA, Rep 2 Pull-down at 12 hours w…
- GSM8651786 RNA-seq at 12 hours with Control miRNA, Rep 3 RNA-seq at 12 hours wit…
- GSM8651787 Pull-down at 12 hours with Control miRNA, Rep 3 Pull-down at 12 hours w…
- GSM8651788 RNA-seq at 12 hours with miR-497-5p-RE miRNA, Rep 1 RNA-seq at 12 hours wit…
- GSM8651789 Pull-down at 12 hours with miR-497-5p-RE miRNA, Rep 1 Pull-down at 12 hours w…
- GSM8651790 RNA-seq at 12 hours with miR-497-5p-RE miRNA, Rep 2 RNA-seq at 12 hours wit…
- GSM8651791 Pull-down at 12 hours with miR-497-5p-RE miRNA, Rep 2 Pull-down at 12 hours w…
- GSM8651792 RNA-seq at 12 hours with miR-497-5p-RE miRNA, Rep 3 RNA-seq at 12 hours wit…
- GSM8651793 Pull-down at 12 hours with miR-497-5p-RE miRNA, Rep 3 Pull-down at 12 hours w…
- GSM8651794 RNA-seq at 72 hours with Control miRNA, Rep 1 RNA-seq at 72 hours wit…
- GSM8651795 Pull-down at 72 hours with Control miRNA, Rep 1 Pull-down at 72 hours w…
- GSM8651796 RNA-seq at 72 hours with Control miRNA, Rep 2 RNA-seq at 72 hours wit…
- GSM8651797 Pull-down at 72 hours with Control miRNA, Rep 2 Pull-down at 72 hours w…
- GSM8651798 RNA-seq at 72 hours with Control miRNA, Rep 3 RNA-seq at 72 hours wit…
- GSM8651799 Pull-down at 72 hours with Control miRNA, Rep 3 Pull-down at 72 hours w…
- GSM8651800 RNA-seq at 72 hours with miR-497-5p-RE miRNA, Rep 1 RNA-seq at 72 hours wit…
- GSM8651801 Pull-down at 72 hours with miR-497-5p-RE miRNA, Rep 1 Pull-down at 72 hours w…
- GSM8651802 RNA-seq at 72 hours with miR-497-5p-RE miRNA, Rep 2 RNA-seq at 72 hours wit…
- GSM8651803 Pull-down at 72 hours with miR-497-5p-RE miRNA, Rep 2 Pull-down at 72 hours w…
- GSM8651804 RNA-seq at 72 hours with miR-497-5p-RE miRNA, Rep 3 RNA-seq at 72 hours wit…
- GSM8651805 Pull-down at 72 hours with miR-497-5p-RE miRNA, Rep 3 Pull-down at 72 hours w…
- GSE292620 Genome-wide CRISPR Screen Identifies BUB1 Kinase as a Druggable Vulnerability in Malignant Pleural Mesothelioma 12 samples same disease briefing · shares mesothelioma, identifies
- GSE190597 Single cell view of tumor microenvironment gradients in pleural mesothelioma 34 samples same disease briefing · shares mesothelioma
- GSE327167 Single-cell RNA-seq profiling of pleural mesothelioma and comparator pleural specimens 113 samples same disease briefing · shares mesothelioma
- GSE51024 Gene Expression of Malignant Pleural Mesothelioma Tumor and paired Normal Lung tissue 96 samples same disease briefing · shares mesothelioma
- GSE272176 PD-1 blockade mitigates surgery-induced immunosuppression and increases the efficacy of photodynamic therapy for malignant pleural mesothelioma 82 samples same disease briefing · shares mesothelioma
- GSE2549 Malignant pleural mesothelioma 54 samples same disease briefing · shares mesothelioma
- GSE262853 Gene expression analysis in mesothelioma cell lines with and without K-975 treatment 36 samples same disease briefing · shares mesothelioma
- GSE250038 Gene expression data from precision cut tumor slices from head and neck or mesothelioma tumors 26 samples same disease briefing · shares mesothelioma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.