IL-2/IL-15 signaling induces NK cell production of FLT3LG which augments anti-PD-1 immunotherapy
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- IL2/IL15 Signaling Induces NK Cell Production of FLT3LG, Augmenting Anti-PD-1 ImmunotherapyCancer immunology research · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282979_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1191402 and SRA study SRP548096. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8653883 M1_CD11b+ CD69-
- GSM8653884 M1_CD11b+ CD69+
- GSM8653885 M1_CD27+ CD69+
- GSM8653886 M1_CD27+ CD69-
- GSM8653887 M2_CD11b+ CD69-
- GSM8653888 M2_CD11b+ CD69+
- GSM8653889 M2_CD27+ CD69+
- GSM8653890 M2_CD27+ CD69-
- GSM8653891 M3_CD11b+ CD69-
- GSM8653892 M3_CD11b+ CD69+
- GSM8653893 M3_CD27+ CD69+
- GSM8653894 M3_CD27+ CD69-
- GSM8653895 M4_CD11b+ CD69-
- GSM8653896 M4_CD11b+ CD69+
- GSM8653897 M4_CD27+ CD69+
- GSM8653898 M4_CD27+ CD69-
- GSM8653899 M5_CD11b+ CD69-
- GSM8653900 M5_CD11b+ CD69+
- GSM8653901 M5_CD27+ CD69+
- GSM8653902 M5_CD27+ CD69-
- GSM8653903 M6_CD11b+ CD69-
- GSM8653904 M6_CD11b+ CD69+
- GSM8653905 M6_CD27+ CD69+
- GSM8653906 M6_CD27+ CD69-
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- GSE263274 Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies 45 samples shares anti-pd-1, immunotherapy
- GSE266110 7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas 40 samples shares anti-pd-1, immunotherapy
- GSE262867 Pancreatic Beta-Cell IL-22 Receptor Deficiency Induces Age-Dependent Dysregulation of Insulin Biosynthesis and Systemic Glucose Homeostasis 10 samples shares il-2, induces
- GSE249674 Intratumoral administration of lipid nanoparticles carrying mRNA encoding for IL-21, IL-7, and 4-1BBL induces anti-tumor immunity in preclinical tumor models. 6 samples shares il-2, induces
- GSE263524 Inhibition of MBTPS1 reprograms cold into inflamed tumors and potentiates anti-PD-1 immunotherapy [scRNA-seq] 2 samples shares anti-pd-1, immunotherapy
- GSE298051 TNG260, a novel small-molecule CoREST inhibitor, sensitizes STK11-mutant tumors to anti-PD-1 immunotherapy 24 samples shares anti-pd-1, immunotherapy
- GSE313261 Global transcriptome analysis of IL-33, IL-25, IL-13, TSLP, IL-4, and IL-9 overexpression in mouse spleen 49 samples shares il-2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.