Schlafen 5 (SLFN5) is an Intracellular Immune Checkpoint and controls Interferon (IFN) Responses in Pancreatic Ductal Adenocarcinoma (PDAC)
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Pancreatic cancerThis series is part of our curated briefing on it.
- Samples
- 14 samples: 4 × PANC-1 cells, WT, UT vs 4 × PANC-1 cells, SLFN5 KO, IFN vs 3 × PANC-1 cells, WT, IFN vs 3 × PANC-1 cells, SLFN5 KO, UTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282985_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1191415 and SRA study SRP548051. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8653993 PANC-1 cells, WT, UT 1 PANC-1 cells, WT, UT
- GSM8653994 PANC-1 cells, WT, UT 2 PANC-1 cells, WT, UT
- GSM8653995 PANC-1 cells, WT, UT 3 PANC-1 cells, WT, UT
- GSM8653996 PANC-1 cells, WT, UT 4 PANC-1 cells, WT, UT
- GSM8653997 PANC-1 cells, WT, IFN 1 PANC-1 cells, WT, IFN
- GSM8653998 PANC-1 cells, WT, IFN 2 PANC-1 cells, WT, IFN
- GSM8653999 PANC-1 cells, WT, IFN 3 PANC-1 cells, WT, IFN
- GSM8654000 PANC-1 cells, SLFN5 KO, UT 1 PANC-1 cells, SLFN5 KO,…
- GSM8654001 PANC-1 cells, SLFN5 KO, UT 2 PANC-1 cells, SLFN5 KO,…
- GSM8654002 PANC-1 cells, SLFN5 KO, UT 3 PANC-1 cells, SLFN5 KO,…
- GSM8654003 PANC-1 cells, SLFN5 KO, IFN 1 PANC-1 cells, SLFN5 KO,…
- GSM8654004 PANC-1 cells, SLFN5 KO, IFN 2 PANC-1 cells, SLFN5 KO,…
- GSM8654005 PANC-1 cells, SLFN5 KO, IFN 3 PANC-1 cells, SLFN5 KO,…
- GSM8654006 PANC-1 cells, SLFN5 KO, IFN 4 PANC-1 cells, SLFN5 KO,…
- GSE150043 Deeper insight into Pancreatic Ductal Adenocarcinoma (PDAC) survival heterogeneity using integrative analyses of individual and global transcriptome based networks 19 samples same disease briefing · shares pdac, adenocarcinoma, pancreatic
- GSE179351 Radiation Therapy Inhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial 54 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE288221 RNA sequencing human melanoma, glioblastoma and pancreatic adenocarcinoma cell lines 32 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE111672 Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas 23 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE224502 RNA-Seq profiles of pancreatic adenocarcinoma PANC-1 and osteosarcoma U2OS cells with Pin1 knocking down 18 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE135731 Genome-wide identification of circular RNAs with critical roles in pancreatic ductal adenocarcinoma 3 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE71729 Virtual Microdissection of Pancreatic Ductal Adenocarcinoma Reveals Tumor and Stroma Subtypes. 357 samples same disease briefing · shares adenocarcinoma, pancreatic
- GSE102238 Gene expression signatures associated with Perineural Invasion in pancreatic ductal adenocarcinoma 100 samples same disease briefing · shares adenocarcinoma, pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.