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Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis

GSE283093 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/12 Platform GPL28330
Summary
Becn1 deficiency in the megakaryocytic lineage reduces sex hormone-binding globulin (SHBG), thus releasing testosterone into the blood and ultimately leading to increased bone mass and improved bone quality.
Published in
Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis
Li L, Zhao C, Zhang R et al. · Bone research 2025 · PMID 40032858 · doi:10.1038/s41413-025-00410-7
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Also filed as BioProject PRJNA1191849 and SRA study SRP548220. Searching any of these in the dataset finder brings you back here.

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