The histone acetyltransferase MOZ is a molecular dependency and therapeutic target in NUP98-rearranged acute myeloid leukemia [WGS, ATACseq, CUT&RUN, scRNAseq]
Single-cell RNA-seq · human · 38 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Homo sapiens (human)
- Samples
- 38 samples: 30 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid LeukemiaCancer discovery · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283096_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1191857 and SRA study SRP548257. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 38 sample titles: 30 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8655941 NM50_primary_5_WGS
- GSM8655942 NM50_primary_6_WGS
- GSM8655943 NM50_primary_7_WGS
- GSM8655944 NM50_primary_9_WGS
- GSM8655945 NM50_secondary_76_WGS
- GSM8655946 NM50_secondary_79_WGS
- GSM8655947 NM50_tertiary_21_WGS
- GSM8655948 FCL030_WGS
- GSM8655949 FCL085_WGS
- GSM8655950 FCL087_WGS
- GSM8655951 FCL009_WGS
- GSM8655952 FCL016_WGS
- GSM8655953 FCL091_WGS
- GSM8655954 MSKG5191_ATACseq_vehicle_rep1
- GSM8655955 MSKG5191_ATACseq_vehicle_rep2
- GSM8655956 MSKG5191_ATACseq_vehicle_rep3
- GSM8655957 MSKG5191_ATACseq_SNDX_rep1
- GSM8655958 MSKG5191_ATACseq_SNDX_rep2
- GSM8655959 MSKG5191_ATACseq_SNDX_rep3
- GSM8655960 MSKG5191_ATACseq_PF_rep1
- GSM8655961 MSKG5191_ATACseq_PF_rep2
- GSM8655962 MSKG5191_ATACseq_PF_rep3
- GSM8655963 MSKG5191_ATACseq_Combo_rep1
- GSM8655964 MSKG5191_ATACseq_Combo_rep2
- GSM8655965 MSKG5191_ATACseq_Combo_rep3
- GSM8655966 MSKG5191_scRNAseq_vehicle
- GSM8655967 MSKG5191_scRNAseq_SNDX
- GSM8655968 MSKG5191_scRNAseq_PF
- GSM8655969 MSKG5191_scRNAseq_Combo
- GSM8975148 CHRF_CUTRUN_IgG
- GSM8975149 CHRF_CUTRUN_NUP98
- GSM8975150 CHRF_CUTRUN_MOZ
- GSM8975151 CHRF_CUTRUN_KMT2A
- GSM8975152 CHRF_CUTRUN_Menin
- GSM8975153 MSKG5191_5day_scRNAseq_vehicle
- GSM8975154 MSKG5191_5day_scRNAseq_SNDX
- GSM8975155 MSKG5191_5day_scRNAseq_PF
- GSM8975156 MSKG5191_5day_scRNAseq_Combo
- GSE283531 MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia [RNA-Seq] 54 samples shares moz, cut, acetyltransferase, nup98-rearranged, therapeutic
- GSE218716 EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition [ChIP-Seq/Cut&Run-Seq] 156 samples shares cut, run
- GSE253753 Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia 126 samples shares cut, run
- GSE298543 Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum [CUT&RUN] 88 samples shares cut, run
- GSE253750 Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia [Cut&Run] 87 samples shares cut, run
- GSE299380 KAT6A Chimeras Forms a Self-Reinforcing Epigenetic Module with NURF and MLL/COMPASS in AML [CUT&Run] 33 samples shares cut, run
- GSE270774 MYC couples SWI/SNF and metabolic reprogramming to sustain minimal residual disease in mTORC1-activated cancer cells [CUT&RUN, ATAC-seq] 32 samples shares cut, run
- GSE253748 Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia [RNA-seq] 29 samples shares cut, run
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.