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Mechanism of pyroptosis of pancreatic cancer induced by arachidonic acid

GSE283340 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/12/08 Platform GPL21290
Summary
Pancreatic cancer is one of the most deadly malignant tumors, and its treatment is scarce. This study found that arachidonic acid can induce pyroptosis of pancreatic cancer both in vitro and in vivo, and can cause immune cell infiltration. Arachidonic acid can be used as a tumor killing drug and an immunotherapy activator, which provides a new idea for the treatment of pancreatic cancer.
Published in
Arachidonic acid induces pyroptosis via a non-autophagic function of mitophagy and enhances immunotherapy in a PDAC model
Chu T, Liu Z, Liu H et al. · Nature communications 2026 · PMID 41519804 · doi:10.1038/s41467-025-68267-2
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Also filed as BioProject PRJNA1193484 and SRA study SRP549131. Searching any of these in the dataset finder brings you back here.

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