GEO series
HUMAN ALVEOLAR MACROPHAGE FUNCTION IS IMPAIRED IN TUBERCULOSIS CONTACTS WITH DIABETES
GSE283452
Homo sapiens
Expression profiling by high throughput sequencing
89 samples
2025/12/31
GPL21290
Summary
Patients with type 2 diabetes (T2D) are more susceptible to Mycobacterium tuberculosis (M.tb) infection and severe tuberculosis (TB). The underlying mechanisms contributing to this remain largely unknown. To fill this critical knowledge gap, we obtained human alveolar macrophages (HAMs) and monocyte-derived macrophages (MDMs) from TB-exposed individuals with and without T2D in South Africa. We infected HAMs and MDMs ex vivo with live M.tb then collected RNA for RNAseq after 2, 24, 72h.
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Paper (PMID 41330113) ↗
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