Aggravated cardiac dysfunction in CKD post-infarction

Uremic cardiomyopathy is a clinically highly relevant cause of cardiovascular events in patients with chronic kidney disease (CKD). Additionally, after acute myocardial infarction (MI), CKD-patients exhibit an increased risk of death. To investigate the underlying molecular mechanisms causing the adverse effects of CKD on cardicac outcome after MI, male mice were fed with an adenine-supplemented diet combined with western type diet (CKD mice) or with western type diet only (control mice). Invasive heart function evaluation and histological analyses were performed 7 days after MI-induction through left anterior descending artery (LAD) ligation. For a deeper look on molecular level, RNA sequencing of heart tissue was performed.