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The interplay between oxytocin receptor and YAP in regulating gastric cancer progression

GSE283517 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/11 Platform GPL23227
Summary
Gastric cancer (GC) is one of the most lethal malignancies worldwide, but the effective therapeutic targets for GC is still limited. Accumulated evidence implicates the over-activation of Hippo/YAP axis in GC, while pharmaceutical targeting YAP could be a plausible strategy for GC treatment. Thus, it is of great clinical significance to identify novel hits for Hippo/YAP axis in GC. In our study, we identified oxytocin receptor (OXTR) as an important regulator of Hippo/YAP axis. RNA sequence analysis revealed the OXTR depletion inhibited the expression of Hippo target genes in whole genomic scale.
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Also filed as BioProject PRJNA1194148 and SRA study SRP549408. Searching any of these in the dataset finder brings you back here.

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