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Suppression of Notch during efferocytosis prevents macrophages inflammatory polarization [SLAM-seq]

GSE283549 Mus musculus Expression profiling by high throughput sequencing; Other 8 samples Submitted 2026/01/08 Platform GPL24247
Summary
We investigated the mechanism of suppression of Notch during efferocytosis. Genetically activation of Notch or ablation of Rubicon in marophages induced pro-inflammatory polarization and enhance anti-tumor effect.
Published in
Exclusion of Notch from the contact site during efferocytosis restricts anticancer immunity
Li Z, Xu B, Sharma P et al. · Nature immunology 2026 · PMID 41776100 · doi:10.1038/s41590-026-02452-3
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Also filed as BioProject PRJNA1194508 and SRA study SRP549556. Searching any of these in the dataset finder brings you back here.

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