GEO series
NNMT promotes tubular senescence and fibrosis in chronic kidney disease (db/m and db/db mice kidney)
GSE283610
Mus musculus
Expression profiling by high throughput sequencing
17 samples
2025/11/20
GPL30172
Summary
Diabetic kidney disease is the leading cause of chronic kidney disease. db/db mice, which carry a deletion mutation resulting in a dysfunctional leptin receptor, exhibit hyperphagia, obesity, and elevated insulin levels, making them a widely used preclinical model of diabetic kidney disease. At 16 weeks of age, db/db mice showed enriched transcriptomic signatures of cellular senescence in their kidneys compared to control db/m mice.
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Paper (PMID 41543936) ↗
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