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Patients who received abatacept for graft versus host disease prophylaxis have lower peri-engraftment NETosis and less endothelial injury

GSE283630 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/30 Platform GPL21697
Summary
Abatacept decreases risk of aGVHD in adult and pediatric patient populations, but its effect on other clinical outcomes of HSCT has not been well studied. Abatacept’s effect in reducing GVHD has been linked to T-cell dependent mechanisms, but it’s effect on neutrophils and completement activation is largely unknown. In this study we analyzed the effect of abatacept prophylaxis in clinical outcomes of HSCT and explored other potential mechanisms.
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Also filed as BioProject PRJNA1194644 and SRA study SRP549667. Searching any of these in the dataset finder brings you back here.

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