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Single-cell RNA sequencing of nicotine-exposed testes reveals differences in cell proportion and transcription

GSE283769 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/30 Platform GPL34290
Summary
We have conducted single-cell RNA sequencing using 10x Genomics scRNAseq to explore the biological effects of nicotine exposure on mice testes. Previous studies have shown that nicotine exposure can alter male fertility, whereas the molecular changes in testicular tissue remain elusive. Here, we demonstrated the effects of nicotine exposure on cell proportion and transcription in testes, providing new insights into the mechanisms by which smoking affects male fertility.
Published in
Mechanisms and reversibility of nicotine-induced spermatogenesis impairment and DNA methylation changes
Cui J, Wang C, Zheng Y et al. · Communications biology 2025 · PMID 40665023 · doi:10.1038/s42003-025-08493-y
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Also filed as BioProject PRJNA1195558 and SRA study SRP550055. Searching any of these in the dataset finder brings you back here.

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