Effects of attenuating astrocytic Ca2+ activity in the medial prefrontal cortex with iβARK on transcriptional profiles in 5xFAD mice
RNA-seq (gene expression) · mouse · 25 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 25 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283790_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1195586 and SRA study SRP550069. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 25 samples.
How we read this: 6 replicated groups read from 25 sample titles; they account for 25 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8672307 male, WT-mCherry, replicate 1 male, WT-mCherry,
- GSM8672308 male, WT-mCherry, replicate 2 male, WT-mCherry,
- GSM8672309 male, WT-mCherry, replicate 3 male, WT-mCherry,
- GSM8672310 male, WT-mCherry, replicate 4 male, WT-mCherry,
- GSM8672311 male, 5xFAD-mCherry, replicate 1 male, 5xFAD-mCherry,
- GSM8672312 male, 5xFAD-mCherry, replicate 2 male, 5xFAD-mCherry,
- GSM8672313 male, 5xFAD-mCherry, replicate 3 male, 5xFAD-mCherry,
- GSM8672314 male, 5xFAD-mCherry, replicate 4 male, 5xFAD-mCherry,
- GSM8672315 male, 5xFAD-iβARK, replicate 1 male, 5xFAD-iβARK,
- GSM8672316 male, 5xFAD-iβARK, replicate 2 male, 5xFAD-iβARK,
- GSM8672317 male, 5xFAD-iβARK, replicate 3 male, 5xFAD-iβARK,
- GSM8672318 female, WT-mCherry, replicate 1 female, WT-mCherry,
- GSM8672319 female, WT-mCherry, replicate 2 female, WT-mCherry,
- GSM8672320 female, WT-mCherry, replicate 3 female, WT-mCherry,
- GSM8672321 female, WT-mCherry, replicate 4 female, WT-mCherry,
- GSM8672322 female, WT-mCherry, replicate 5 female, WT-mCherry,
- GSM8672323 female, 5xFAD-mCherry, replicate 1 female, 5xFAD-mCherry,
- GSM8672324 female, 5xFAD-mCherry, replicate 2 female, 5xFAD-mCherry,
- GSM8672325 female, 5xFAD-mCherry, replicate 3 female, 5xFAD-mCherry,
- GSM8672326 female, 5xFAD-mCherry, replicate 4 female, 5xFAD-mCherry,
- GSM8672327 female, 5xFAD-mCherry, replicate 5 female, 5xFAD-mCherry,
- GSM8672328 female, 5xFAD-iβARK, replicate 1 female, 5xFAD-iβARK,
- GSM8672329 female, 5xFAD-iβARK, replicate 2 female, 5xFAD-iβARK,
- GSM8672330 female, 5xFAD-iβARK, replicate 3 female, 5xFAD-iβARK,
- GSM8672331 female, 5xFAD-iβARK, replicate 4 female, 5xFAD-iβARK,
- GSE303725 Effects of attenuating astrocytic Ca2+ activity in the medial prefrontal cortex with iβARK on transcriptional profiles in wild-type mice. 17 samples shares ark, attenuating, astrocytic, prefrontal, activity, profiles, medial
- GSE319850 Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice 23 samples shares 5xfad, astrocytic
- GSE211550 Macrophages adopt mural cell function and marker expression for vascular support following ischemia 1509 samples shares ark
- GSE292885 Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation 210 samples shares ark
- GSE299686 Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma [bulk RNA-seq] 178 samples shares ark
- GSE255004 Sensory Flicker Stimulation of 5xFAD Mice Activates Immune Pathways in a Frequency and Time Dependent Manner 176 samples shares 5xfad
- GSE300534 Brain Mecp2 Genetic Dosage and Gene Therapy Shape Multi-omics Signatures and Biomarkers in Rett Syndrome [1] 137 samples shares ark
- GSE300536 Brain Mecp2 Genetic Dosage and Gene Therapy Shape Multi-omics Signatures and Biomarkers in Rett Syndrome [2] 137 samples shares ark
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.