Sensory Flicker Stimulation of 5xFAD Mice Activates Immune Pathways in a Frequency and Time Dependent Manner
RNA-seq (gene expression) · mouse · 176 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 176 samples: 176 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255004_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1073179 and SRA study SRP488010. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 176 sample titles: 176 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8062251 5xFAD 10Hz 0.5hr Rep1 Hip
- GSM8062252 5xFAD 10Hz 0.5hr Rep1 VC
- GSM8062253 5xFAD 10Hz 0.5hr Rep2 Hip
- GSM8062254 5xFAD 10Hz 0.5hr Rep2 VC
- GSM8062255 5xFAD 10Hz 0.5hr Rep3 Hip
- GSM8062256 5xFAD 10Hz 0.5hr Rep3 VC
- GSM8062257 5xFAD 10Hz 0.5hr Rep4 Hip
- GSM8062258 5xFAD 10Hz 0.5hr Rep4 VC
- GSM8062259 5xFAD 10Hz 0.5hr Rep5 Hip
- GSM8062260 5xFAD 10Hz 0.5hr Rep5 VC
- GSM8062261 5xFAD 10Hz 0.5hr Rep6 Hip
- GSM8062262 5xFAD 10Hz 0.5hr Rep6 VC
- GSM8062263 5xFAD 10Hz 0.5hr Rep7 Hip
- GSM8062264 5xFAD 10Hz 0.5hr Rep7 VC
- GSM8062265 5xFAD 10Hz 1hr Rep1 Hip
- GSM8062266 5xFAD 10Hz 1hr Rep1 VC
- GSM8062267 5xFAD 10Hz 1hr Rep2 Hip
- GSM8062268 5xFAD 10Hz 1hr Rep2 VC
- GSM8062269 5xFAD 10Hz 1hr Rep3 Hip
- GSM8062270 5xFAD 10Hz 1hr Rep3 VC
- GSM8062271 5xFAD 10Hz 1hr Rep4 Hip
- GSM8062272 5xFAD 10Hz 1hr Rep4 VC
- GSM8062273 5xFAD 10Hz 1hr Rep5 Hip
- GSM8062274 5xFAD 10Hz 1hr Rep5 VC
- GSM8062275 5xFAD 10Hz 1hr Rep6 Hip
- GSM8062276 5xFAD 10Hz 1hr Rep6 VC
- GSM8062277 5xFAD 10Hz 4hr Rep1 Hip
- GSM8062278 5xFAD 10Hz 4hr Rep1 VC
- GSM8062279 5xFAD 10Hz 4hr Rep2 Hip
- GSM8062280 5xFAD 10Hz 4hr Rep2 VC
- GSM8062281 5xFAD 10Hz 4hr Rep3 Hip
- GSM8062282 5xFAD 10Hz 4hr Rep3 VC
- GSM8062283 5xFAD 10Hz 4hr Rep4 Hip
- GSM8062284 5xFAD 10Hz 4hr Rep4 VC
- GSM8062285 5xFAD 10Hz 4hr Rep5 Hip
- GSM8062286 5xFAD 10Hz 4hr Rep5 VC
- GSM8062287 5xFAD 10Hz 4hr Rep6 Hip
- GSM8062288 5xFAD 10Hz 4hr Rep6 VC
- GSM8062289 5xFAD 20Hz 0.5hr Rep1 Hip
- GSM8062290 5xFAD 20Hz 0.5hr Rep1 VC
+ 136 more — browse all 176 samples with per-sample file links →
- GSE306854 Exploring the sex and estrous cycle-dependent differences in microglia response to amyloid-beta pathology in female and male C57BL6/J (WT) and 5xFAD using bulk mRNAseq of isolated microglia. 24 samples shares 5xfad, dependent
- GSE240815 Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice 16 samples shares stimulation, sensory
- GSE338930 A Blood-Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN-Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1 8 samples shares activates, dependent
- GSE272491 The effect of chronic intermittent hypoxia (CIH) on amyloid pathology in 5XFAD mice 39 samples shares 5xfad
- GSE276797 Gene expression profile at single cell level of immune cells from the deep cervical lymph nodes (dCLNs), superficial cervical lymph nodes (sCLNs), and inguinal lymph nodes (iLNs) of wild-type (WT) and Alzheimer's disease (AD) transgenic animals (5xFAD) 34 samples shares 5xfad
- GSE302153 Study of Molecular and Transcriptomic Age-related Changes in the Dorsal and Ventral Areas of Hippocampus in the 5xFAD Mouse Model of Alzheimer’s Disease 32 samples shares 5xfad
- GSE296886 Effect of a natural product derivative on gene expression signatures in 5xFAD transgenic mice 25 samples shares 5xfad
- GSE283790 Effects of attenuating astrocytic Ca2+ activity in the medial prefrontal cortex with iβARK on transcriptional profiles in 5xFAD mice 25 samples shares 5xfad
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.