Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in endometriod carcinomas [ATAC/ChIP/RNA]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 145 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Endometrial cancerThis series is part of our curated briefing on it.
- Samples
- 145 samples: 145 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomasNature genetics · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283800_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1195678 and SRA study SRP550297. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 5 samples read as cases, 33 as controls.
How we read this: Read from 145 sample titles: 145 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8303454 20210601_JSL001_ATAC_AN3CA_pos_ARID1A_Rep1
- GSM8303455 20210601_JSL002_ATAC_AN3CA_pos_ARID1A_Rep2
- GSM8303456 20210601_JSL003_ATAC_AN3CA_neg_DOX_Rep1
- GSM8303457 20210601_JSL004_ATAC_AN3CA_neg_DOX_Rep2
- GSM8303458 20210601_JSL005_ATAC_AN3CA_none_Rep1
- GSM8303459 20210601_JSL006_ATAC_AN3CA_none_Rep2
- GSM8303460 20210601_JSL007_ATAC_AN3CA_dBRD9_Rep1
- GSM8303461 20210601_JSL008_ATAC_AN3CA_dBRD9_Rep2
- GSM8303462 20210601_JSL009_ATAC_AN3CA_DMSO_Rep1
- GSM8303463 20210601_JSL010_ATAC_AN3CA_DMSO_Rep2
- GSM8303464 20210601_JSL011_ATAC_AN3CA_C12_Rep1
- GSM8303465 20210601_JSL012_ATAC_AN3CA_C12_Rep2
- GSM8303466 20240125_GXATAC097_AN3CA_parental_rep1
- GSM8303467 20240125_GXATAC098_AN3CA_ARID1A_rep1
- GSM8303468 20240125_GXATAC099_AN3CA_ARID1B_rep1
- GSM8303469 20240125_GXATAC100_AN3CA_ARID1A_ARID1B_c1_rep1
- GSM8303470 20240125_GXATAC101_AN3CA_ARID1A_ARID1B_c2_rep1
- GSM8303471 20240125_GXATAC102_AN3CA_parental_rep2
- GSM8303472 20240125_GXATAC103_AN3CA_ARID1A_rep2
- GSM8303473 20240125_GXATAC104_AN3CA_ARID1B_rep2
- GSM8303474 20240125_GXATAC105_AN3CA_ARID1A_ARID1B_c1_rep2
- GSM8303475 20240125_GXATAC106_AN3CA_ARID1A_ARID1B_c2_rep2
- GSM8303476 20230613_GXChIP025_AN3CA_negDox_BRG1
- GSM8303477 20230613_GXChIP026_AN3CA_posDox_BRG1
- GSM8303478 20230613_GXChIP027_AN3CA_negDox_BRD9
- GSM8303479 20230613_GXChIP028_AN3CA_posDox_BRD9
- GSM8303480 20230613_GXChIP029_AN3CA_negDox_ARID1A
- GSM8303481 20230613_GXChIP030_AN3CA_posDox_ARID1A
- GSM8303482 20230613_GXChIP031_AN3CA_negDox_SS18
- GSM8303483 20230613_GXChIP032_AN3CA_posDox_SS18
- GSM8303484 20230613_GXChIP037_AN3CA_negDox_input
- GSM8303485 20230613_GXChIP038_AN3CA_posDox_input
- GSM8303486 20230801_GXChIP055_AN3CA_negDox_PBRM1
- GSM8303487 20230801_GXChIP056_AN3CA_posDox_PBRM1
- GSM8303488 20230801_GXChIP057_AN3CA_negDox_GLTSCR
- GSM8303489 20230801_GXChIP058_AN3CA_posDox_GLTSCR
- GSM8303490 20230801_GXChIP063_AN3CA_negDox_H3K27ac
- GSM8303491 20230801_GXChIP064_AN3CA_posDox_H3K27ac
- GSM8303492 20230801_GXChIP065_AN3CA_negDox_input
- GSM8303493 20230801_GXChIP066_AN3CA_posDox_input
+ 105 more — browse all 145 samples with per-sample file links →
- GSE307568 Patient-derived organoid – immune cell co-culture platform for therapeutics discovery in high-grade endometrial cancer 189 samples same disease briefing
- GSE212217 Distinct Mechanisms of Mismatch-Repair Deficiency Delineate Two Modes of Response to Anti–PD-1 Immunotherapy in Endometrial Carcinoma 104 samples same disease briefing
- GSE17025 Gene Expression Analysis of Stage I Endometrial Cancers 103 samples same disease briefing
- GSE323968 Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer 56 samples same disease briefing
- GSE247793 Cell cycle checkpoint proficiency of endometrial cancer cells 42 samples same disease briefing
- GSE323965 Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer [RNA-Seq] 39 samples same disease briefing
- GSE312906 Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer 37 samples same disease briefing
- GSE235241 Enhancer plasticity in endometrial tumorigenesis demarcates non-coding driver mutations and 3D genome alterations to stimulate oncogene expression 36 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.