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Disruption of the Integrator complex triggers the Integrated Stress Response through formation of double-stranded RNA [48h_INTS8_RNAseq]

GSE283862 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/16 Platform GPL24676
Summary
Acute loss of INT induces transcription factors that initiate stress-responses like the Integrated Stress Response (ISR). Inefficient elongation upon INT loss enables termination in introns and dsRNA formation. dsRNA is recognized by PKR, which persistently activates the ISR in samples from patients with INT mutations
Published in
Integrator loss leads to dsRNA formation that triggers the integrated stress response
Baluapuri A, Zhao NC, Marina RJ et al. · Cell 2025 · PMID 40233738 · doi:10.1016/j.cell.2025.03.025
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Also filed as BioProject PRJNA1195926 and SRA study SRP550257. Searching any of these in the dataset finder brings you back here.

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