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Integrated transcriptomic and epigenomic profiling of mouse lung cells at the single-cell level

GSE284046 Mus musculus Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/31 Platform GPL21626
Summary
Our previous scRNA-seq data suggest that immune and stromal cells exhibit memory properties that contribute to the long-term regulation of lung allergic responses, which are cross-regulated by the co-administration of TLR ligands or bacterial extracts. To further investigate these mechanisms, we performed single-cell multiome sequencing (scMulti-omics) to integrate transcriptomic and epigenomic profiling, focusing on the characterization of immune and stromal cell populations during long-term resolution.
Published in
Long-term inhibition of protease hypersensitivity by initial immunological cross-regulation and epigenetic memory in lung stromal cells
Ryu J, Blondeau A, Mirabeau O et al. · Nature immunology 2026 · PMID 41776102 · doi:10.1038/s41590-026-02439-0
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Direct links to NCBI, no account and no request form: the whole study as GSE284046_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1196899 and SRA study SRP550859. Searching any of these in the dataset finder brings you back here.

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