Novel effects of reverse transcriptase inhibitor supplementation in skeletal muscle of old mice
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Novel effects of reverse transcriptase inhibitor supplementation in skeletal muscle of old micePhysiological genomics · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE284098_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1197066 and SRA study SRP550963. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8677917 Old untreated female 1 Old untreated female
- GSM8677918 Old untreated female 2 Old untreated female
- GSM8677919 Old untreated female 3 Old untreated female
- GSM8677920 Old untreated male 1 Old untreated male
- GSM8677921 Old untreated male 3 Old untreated male
- GSM8677922 Old untreated male 6 Old untreated male
- GSM8677923 Old 3TC treated female 4 Old 3TC treated female
- GSM8677924 Old 3TC treated female 5 Old 3TC treated female
- GSM8677925 Old 3TC treated female 8 Old 3TC treated female
- GSM8677926 Old 3TC treated male 1 Old 3TC treated male
- GSM8677927 Old 3TC treated male 2 Old 3TC treated male
- GSM8677928 Old 3TC treated male 5 Old 3TC treated male
- GSM8677929 Young untreated female 1 Young untreated female
- GSM8677930 Young untreated female 3 Young untreated female
- GSM8677931 Young untreated female 8 Young untreated female
- GSM8677932 Young untreated male 1 Young untreated male
- GSM8677933 Young untreated male 2 Young untreated male
- GSM8677934 Young untreated male 8 Young untreated male
- GSE325158 Dietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexia [RNA-seq] 12 samples shares supplementation, skeletal, muscle
- GSE237747 Transcriptomic profiling across 20 CC-RIX genetic backgrounds with and without high-fat high-sugar (HFHS) diet, and with and without metformin [skeletal muscle] 703 samples shares skeletal, muscle
- GSE267727 Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, heart, and skeletal muscle tissue from mice fed high-fat, high-sugar diet [heart] 482 samples shares skeletal, muscle
- GSE266549 Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, and skeletal muscle tissue from mice fed high-fat, high-sugar diet. [Adipose] 468 samples shares skeletal, muscle
- GSE271744 Bulk RNAseq of mononucleated cells isolated from resting and regenerating adult and aged skeletal mouse muscle 107 samples shares skeletal, muscle
- GSE226867 Estrogen Effects on Abdominal Skeletal Muscle Fibroblasts in Inguinal Hernia Mouse Model [RNA-Seq] 12 samples shares skeletal, muscle
- GSE308174 Bulk mRNA-seq analysis of mouse skeletal muscle, heart and liver expressing wild-type and mutant H2B 75 samples shares skeletal, muscle
- GSE253735 Loss of skeletal muscle Bmal1 +/- Exercise Training [Mouse liver, heart, inguinal white adipose and lung tissues 64 samples shares skeletal, muscle
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.