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Gene expression profile at single cell level of hepatocytes and non parenchymal cells (NPCs) isolated from a murine model of MASLD

GSE284186 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/02/28 Platform GPL24247
Summary
Metabolic dysfunction-associated steatotic liver disease (MASLD) embraces different conditions, including metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The landscape of cellular abnormalities occurring in the different stages of MASLD as well as the processes which drive MASLD evolution are not completely clarified. We used single cell RNAsequencing (scRNAseq) to unravel cellular heterogeneity affecting livers during the switching from simple steatosis towads MASH and and MASH-fibrosis.
Published in
Single Cell Analysis Reveals the Presence of Novel Intermediate Cells in Both Mice and Patients With Severe MASLD
Meroni M, Pelucchi P, Paolini E et al. · FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 · PMID 41811176 · doi:10.1096/fj.202504360R
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Direct links to NCBI, no account and no request form: the whole study as GSE284186_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1197525 and SRA study SRP551169. Searching any of these in the dataset finder brings you back here.

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