← BioTransfer GEO Dataset Finder
GEO series

Comprehensive transcriptome analysis of the skin in epidermis-specific Nampt cKO mice.

GSE284223 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/11/30 Platform GPL24247
Summary
Nicotinamide adenine dinucleotide (NAD⁺) is essential for cellular metabolism, DNA repair, and stress response. NAD+ is synthesized from nicotinamide, nicotinic acid (collectively termed niacin), and tryptophan. In humans, deficiencies in these nutrients result in pellagra, marked by dermatitis, diarrhea, and dementia. The dermatitis associated with pellagra typically manifests as photodermatosis in sun-exposed areas. This study examined the effects of NAD+ deficiency on skin homeostasis using epidermis-specific Nampt conditional knockout (cKO) mice. These mice displayed substantial NAD⁺ depletion, reduced poly (ADP-ribose) polymerase (PARP) activity, and increased DNA damage, indicated by γH2AX accumulation. Nampt cKO mice also developed spontaneous skin inflammation and epidermal hyperplasia. Here, we provide gene expression profiling of skin tissues using the RNA sequencing for identifying changes in gene expression of Nampt-cKO mice.
Published in
Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis
Seki T, Kim JD, Yahara Y et al. · JCI insight 2026 · PMID 41665963 · doi:10.1172/jci.insight.189177
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE284223_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1198025 and SRA study SRP551321. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.