Transcriptomic analysis of first molars in a mouse model of Loeys-Dietz Syndrome Type II harboring a G357W mutation in the Tgfbr2 gene
RNA-seq (gene expression) · mouse · 22 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 22 samples: 6 × Molar_P5_WT vs 6 × Molar_P5_Het vs 5 × Molar_P11_WT vs 5 × Molar_P11_HetGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Distinctive Amelogenesis Imperfecta in Loeys-Dietz Syndrome Type IIJournal of dental research · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE284226_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1198027 and SRA study SRP551323. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 22 samples.
How we read this: 4 replicated groups read from 22 sample titles; they account for 22 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8680252 Molar_P5_WT_replicate1 Molar_P5_WT
- GSM8680253 Molar_P5_WT_replicate2 Molar_P5_WT
- GSM8680254 Molar_P5_WT_replicate3 Molar_P5_WT
- GSM8680255 Molar_P5_WT_replicate4 Molar_P5_WT
- GSM8680256 Molar_P5_WT_replicate5 Molar_P5_WT
- GSM8680257 Molar_P5_WT_replicate6 Molar_P5_WT
- GSM8680258 Molar_P5_Het_replicate1 Molar_P5_Het
- GSM8680259 Molar_P5_Het_replicate2 Molar_P5_Het
- GSM8680260 Molar_P5_Het_replicate3 Molar_P5_Het
- GSM8680261 Molar_P5_Het_replicate4 Molar_P5_Het
- GSM8680262 Molar_P5_Het_replicate5 Molar_P5_Het
- GSM8680263 Molar_P5_Het_replicate6 Molar_P5_Het
- GSM8680264 Molar_P11_WT_replicate1 Molar_P11_WT
- GSM8680265 Molar_P11_WT_replicate2 Molar_P11_WT
- GSM8680266 Molar_P11_WT_replicate3 Molar_P11_WT
- GSM8680267 Molar_P11_WT_replicate4 Molar_P11_WT
- GSM8680268 Molar_P11_WT_replicate5 Molar_P11_WT
- GSM8680269 Molar_P11_Het_replicate1 Molar_P11_Het
- GSM8680270 Molar_P11_Het_replicate2 Molar_P11_Het
- GSM8680271 Molar_P11_Het_replicate3 Molar_P11_Het
- GSM8680272 Molar_P11_Het_replicate4 Molar_P11_Het
- GSM8680273 Molar_P11_Het_replicate5 Molar_P11_Het
- GSE226610 Transcriptomic analysis of enamel organ in a mouse model of Loeys-Dietz Syndrome Type II harboring a G357W mutation in the Tgfbr2 gene 13 samples shares tgfbr2, g357w, loeys-dietz, harboring, mutation, type
- GSE226611 Transcriptomic analysis of young aortic tissue in a mouse model of Loeys-Dietz Syndrome Type II harboring a G357W mutation in the Tgfbr2 gene 11 samples shares tgfbr2, g357w, loeys-dietz, harboring, mutation, type
- GSE299064 PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation 9 samples shares harboring, mutation
- GSE255810 Transcriptional profiling of mouse embryonic fibroblasts harboring the Fxn G127V mutation 6 samples shares harboring, mutation
- GSE275791 IDH-mutant glioma arises from glial progenitor cells harboring the initial driver mutation 2 samples shares harboring, mutation
- GSE301156 Control and Tgfbr2 cKO Mouse Endometrial Epithelial Organoids +/- E2/MPA Treatment 16 samples shares tgfbr2
- GSE198654 RNA Sequencing of Mrp8-Cre;TGFbR2-fl/fl Lung Neutrophils 6 samples shares tgfbr2
- GSE295782 Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins [scRNA-seq Tgfbr2_cKO] 2 samples shares tgfbr2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.