Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS mutant cancers

Direct links to NCBI, no account and no request form: the whole study as GSE284241_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1198056 and SRA study SRP551349. Searching any of these in the dataset finder brings you back here.

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• GSE327821 Single-molecule, single-cell profiling of linked chromatin states [Single_cell_CoCUT&Tag] 200 samples
• GSE279619 SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation. 124 samples
• GSE280280 Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory circuits During Response to MAPK Inhibition in BRAF-mutant colorectal cancer 36 samples
• GSE327819 Single-molecule, single-cell profiling of linked chromatin states [Bulk_CoCUT&Tag] 35 samples
• GSE278073 Targeting VRK2 Enhances the Efficacy of Anti-PD-1 Therapy in Hepatocellular Carcinoma by Reducing Direct Phosphorylation and Stability of MYC: CUT-TAG sequencing for MYC in hepatocellular carcinoma cells 16 samples
• GSE267470 Dual targeting of processive transcription for Myc-driven circuitry in medulloblastoma [CUT&RUN] 12 samples
• GSE316989 Targeting CDK12/CYCLIN K induces a gene activation program which is mediated by P-TEFb [Cut&RUN] 10 samples
• GSE142751 Genome-wide maps of chromatin state in 142 cancer cell lines [cell line] 855 samples

Search all human ChIP / ATAC / CUT&Tag datasets in GEO →