Pharmacodynamic evaluation of MgIG in animal models of acute and chronic alcoholic fatty liver

Objective: To assess gene expression differences in liver tissues of National Institute on Alcohol Abuse and Alcoholism (NIAAA) mouse models induced by alcohol-containing liquid diets, with or without magnesium isoglycyrrhizinate (MgIG) treatment.Methods: The NIAAA mouse model was established through dietary intervention and divided into three groups: control + saline (n=3), NIAAA + saline (n=3), and NIAAA + MgIG (n=3). After 16 days of modeling, mice were sacrificed, and liver tissues were collected for RNA sequencing analysis. Comparative analysis of gene expression among the three groups was conducted to identify potential therapeutic targets of MgIG.Results: The findings suggest that genes such as Idi1, Acot2, Gstm1, and Ugt1a5 may play a role in mediating the protective effects of MgIG in the NIAAA model.