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Transcriptomic analysis of human induced stem cell-derived endothelial cells and retianl endothelial cells

GSE284350 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/04/02 Platform GPL34284
Summary
This study conducts a comprehensive transcriptome analysis to compare human induced pluripotent stem cell-derived endothelial cells (iECs) with retinal endothelial cells (iRECs). By examining gene expression profiles, we aims to identify molecular distinctions and similarities between these cell types. With an increasing need to develop tissue-specific endothelial cells for more accurate disease modeling and personalized therapies, this work highlights the unique features of retinal endothelial cells. Understanding these differences is crucial, as retinal endothelial cells play a key role in ocular diseases such as diabetic retinopathy and aged-related macular degeneration. Insights from this study could enhance the development of targeted therapies for retinal vascular disorders.
Published in
Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling
Lin YY, Esswein P, Ramirez L et al. · Nature biomedical engineering 2026 · PMID 42380331 · doi:10.1038/s41551-026-01712-9
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Direct links to NCBI, no account and no request form: the whole study as GSE284350_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1198864 and SRA study SRP551722. Searching any of these in the dataset finder brings you back here.

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