Multi-omics integrative approach of senescent endothelial cells and derived extracellular vesicles in a replicative senescence model
Non-coding RNA profiling · human · 18 samples
- What it is
- Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE311040_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
Also filed as BioProject PRJNA1368491 and SRA study SRP648053. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9315791 Senescent HUVECs, Rep A Senescent HUVECs, Rep A
- GSM9315792 Senescent HUVECs, Rep B Senescent HUVECs, Rep B
- GSM9315793 Senescent HUVECs, Rep C Senescent HUVECs, Rep C
- GSM9315794 Early-passage HUVECs, Rep D Early-passage HUVECs, R…
- GSM9315795 Early-passage HUVECs, Rep E Early-passage HUVECs, R…
- GSM9315796 Early-passage HUVECs, Rep F Early-passage HUVECs, R…
- GSM9315797 Senescent EVs, Rep A
- GSM9315798 Senescent EVs, Rep B
- GSM9315799 Senescent EVs, Rep C
- GSM9315800 Early-passage EVs, Rep D
- GSM9315801 Early-passage EVs, Rep E
- GSM9315802 Early-passage EVs, Rep F
- GSM9315803 Senescent HUVECs, Rep A Senescent HUVECs, Rep A
- GSM9315804 Senescent HUVECs, Rep B Senescent HUVECs, Rep B
- GSM9315805 Senescent HUVECs, Rep C Senescent HUVECs, Rep C
- GSM9315806 Early-passage HUVECs, Rep D Early-passage HUVECs, R…
- GSM9315807 Early-passage HUVECs, Rep E Early-passage HUVECs, R…
- GSM9315808 Early-passage HUVECs, Rep F Early-passage HUVECs, R…
- GSE314750 Increased arrhythmic risk in obesity is transduced by adipose tissue-derived extracellular vesicles 30 samples shares extracellular, vesicles, derived
- GSE255877 5-Fluorouracil Treatment Represses Pseudouridine-Containing miRNA Export into Extracellular Vesicles 18 samples shares extracellular, vesicles
- GSE146585 Functional genomics assays, including ChIP-seq, ATAC-seq, RNA-seq, GRO-seq, and in situ Hi-C, in the context of replicative senescence 223 samples shares replicative, senescence
- GSE317901 Unraveling cetuximab response in head and neck cancer with APHRODYTHE, a multi-omics patient-derived xenograft platform 114 samples shares multi-omics, derived
- GSE302211 Extracellular Vesicle Online Knowledge Explorer (EVOKE) - A guiding tool for the selection of methods to prepare extracellular vesicles from human biofluids II 73 samples shares extracellular, vesicles
- GSE237810 Multi-omics analysis of FOXO3 pioneer factor activity reveals distinct networks in proliferating and DNA damage induced senescent cells 65 samples shares multi-omics, senescent
- GSE330283 Endothelial transcriptome remodeling by young and senescent MSCs depends on co-culture mode, ECM, and secreted factors 27 samples shares endothelial, senescent
- GSE217649 Bulk RNA sequencing for gene expression profileing of primary liver sinusoidal endothelial cells and iPSC-derived hepatic endoderm, septum mesenchymal cells, endothelial cells, and liver bud organoids 26 samples shares endothelial, derived
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.