Peptidylarginine deiminase 4 deficiency improves elastase-induced formation of neutrophil extracellular traps and emphysema in mouse lung
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Peptidylarginine Deiminase 4 Deficiency Suppresses Neutrophil Extracellular Trap Formation and Ameliorates Elastase-Induced Emphysema in Mouse LungInternational journal of molecular sciences · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE284684_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1200037 and SRA study SRP552538. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 23 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8690493 KO + PBS lung day1_1 KO + PBS lung day1
- GSM8690494 KO + PBS lung day1_2 KO + PBS lung day1
- GSM8690495 KO + ELS lung day1_1 KO + ELS lung day1
- GSM8690496 KO + ELS lung day1_2 KO + ELS lung day1
- GSM8690497 Wt + PBS lung day1_1 Wt + PBS lung day1
- GSM8690498 Wt + PBS lung day1_2 Wt + PBS lung day1
- GSM8690499 Wt + ELS lung day1_1 Wt + ELS lung day1
- GSM8690500 Wt + ELS lung day1_2 Wt + ELS lung day1
- GSM8690501 KO + PBS lung day14_1 KO + PBS lung day14
- GSM8690502 KO + PBS lung day14_2 KO + PBS lung day14
- GSM8690503 KO + ELS lung day14_1 KO + ELS lung day14
- GSM8690504 KO + ELS lung day14_2 KO + ELS lung day14
- GSM8690505 Wt + PBS lung day14_1 Wt + PBS lung day14
- GSM8690506 Wt + PBS lung day14_2 Wt + PBS lung day14
- GSM8690507 Wt + ELS lung day14_1 Wt + ELS lung day14
- GSM8690508 Wt + ELS lung day14_2 Wt + ELS lung day14
- GSM9024174 KO + PBS lung day1_3 KO + PBS lung day1
- GSM9024175 KO + ELS lung day1_3
- GSM9024176 Wt + PBS lung day1_3 Wt + PBS lung day1
- GSM9024177 Wt + ELS lung day1_3 Wt + ELS lung day1
- GSM9024178 KO + PBS lung day14_3 KO + PBS lung day14
- GSM9024179 KO + ELS lung day14_3 KO + ELS lung day14
- GSM9024180 Wt + PBS lung day14_3 Wt + PBS lung day14
- GSM9024181 Wt + ELS lung day14_3 Wt + ELS lung day14
- GSE272476 Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells [RNA-seq] 30 samples shares extracellular, neutrophil
- GSE287944 Adenine Nucleotide translocase 1 (ANT1) Deficiency Impairs Macrophage Metabolism and Migration, Protecting Against Emphysema in COPD 12 samples shares deficiency, emphysema
- GSE254410 In the aftermath of stroke or myocardial infarction, neutrophil extracellular traps disrupt systemic immunoglobulin production 12 samples shares extracellular, neutrophil
- GSE295926 Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Malformations through Dysregulation of DNA Methylation. 67 samples shares deficiency, formation
- GSE241850 Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer progression via extracellular vesicle transfer of m6A-modified RNAs 57 samples shares extracellular, deficiency
- GSE295428 Spaceflight induces systemic effects on extracellular matrix and immune system in different age-stages 229 samples shares extracellular
- GSE254229 ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice 141 samples shares deficiency
- GSE330865 Multiorgan transcriptomics and circulating extracellular vesicle profiling reveal age-dependent systemic vulnerability to isoflurane anesthesia and surgery 120 samples shares extracellular
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.