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Mandibular monocytes have enhanced osteoclast differentiation and differentially regulated gene expression compared to femur derived monocytes

GSE285067 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/03 Platform GPL34475
Summary
To determine if there are differences between osteoclasts from the mandible and femur of 1-year-old mice we evaluated gene expression and differentiation potential of osteoclast precursors. Osteoclasts from the mandible of 1-year-old mice were larger in size compared to those in the femur, but significantly less in number. The differentially regulated genes with increased expression in the mandible are associated with osteoclast lineage commitment, proliferation, and inflammation; similar to those in the 2-month old mice. Bulk RNA sequencing demonstrated that the mandible had more upregulated genes compared to the femur, and the pathways enriched in the mandible were distinct from those in the femur. Changes in osteoclast precursors due to again may be regulated by different mechanisms in the craniofacial and appendicular regions of the skeleton.
Published in
Mandibular-Derived Monocytes from 1-Year-Old Mice Have Enhanced Osteoclast Differentiation and Differentially Regulated Gene Expression Compared to Femur-Derived Monocytes
Asinas ED, Clark R, Nelson J et al. · Biology 2025 · PMID 40136529 · doi:10.3390/biology14030273
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Also filed as BioProject PRJNA1201126 and SRA study SRP552981. Searching any of these in the dataset finder brings you back here.

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