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RNA-seq analysis of Calreticulin(Calr) knockout LLC cells identified ER stress response

GSE285113 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/24 Platform GPL24247
Summary
To investigate the mechanisms by which Calreticulin inactivation increases tumor sensitivity to T cell-mediated anti-tumor immunity, LLC cells were transduced with sgRNA targeting Calreticulin or a control sgRNA, and transcriptome changes were profiled using paired-end RNA-seq. Our data demonstrated that Calr KO induces an ER stress response.
Published in
Perturbation of calreticulin potentiates CD8+ T cell-mediated antitumor immunity
Tang K, Wu L, Hu Y et al. · The Journal of experimental medicine 2025 · PMID 40833532 · doi:10.1084/jem.20242360
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Also filed as BioProject PRJNA1201200 and SRA study SRP553036. Searching any of these in the dataset finder brings you back here.

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