A phosphorylation switch within the Mediator subunit MED15 controls cellular senescence and cognitive decline [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 10 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 2 × MED15 T603A HaCaT, TGFβ3h, POLII ChIP, vs 2 × WT HaCaT, TGFβ3h, POLII ChIP, vs 2 × MED15 T603A HaCaT, TGFβ3h, FOXA1 ChIP,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive declineCell discovery · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285137_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1201230 and SRA study SRP553072. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 6 samples.
How we read this: 3 replicated groups read from 10 sample titles; they account for 6 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8697140 MED15 T603A HaCaT, TGFβ3h, POLII ChIP, rep1 MED15 T603A HaCaT, TGFβ…
- GSM8697141 MED15 T603A HaCaT, TGFβ3h, POLII ChIP, rep2 MED15 T603A HaCaT, TGFβ…
- GSM8697142 WT HaCaT, TGFβ3h, POLII ChIP, rep1 WT HaCaT, TGFβ3h, POLII…
- GSM8697143 WT HaCaT, TGFβ3h, POLII ChIP, rep2 WT HaCaT, TGFβ3h, POLII…
- GSM8697144 MED15 T603A HaCaT, TGFβ3h, FOXA1 ChIP, rep1 MED15 T603A HaCaT, TGFβ…
- GSM8697145 MED15 T603A HaCaT, TGFβ3h, FOXA1 ChIP, rep2 MED15 T603A HaCaT, TGFβ…
- GSM8697146 WT HaCaT, TGFβ3h, FOXA1 ChIP, rep1
- GSM8697147 WT HaCaT, TGFβ3h, FOXA1 ChIP, rep2
- GSM8697148 MED15 T603A T603A HaCaT, TGFβ3h, Input
- GSM8697149 WT T603A HaCaT, TGFβ3h, Input
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- GSE265881 Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II (ChIP-Seq) 72 samples shares phosphorylation, chip-seq
- GSE269715 Defective RNA processing and ELOA-mediated transcriptional elongation in reversible cellular senescence suggest aging by transcription 40 samples shares senescence, cellular
- GSE324916 Phosphorylation of serines 287/288 in DEK regulates cell-type-specific chromatin occupancy and compaction [ChIP-Seq] 24 samples shares phosphorylation, chip-seq
- GSE278073 Targeting VRK2 Enhances the Efficacy of Anti-PD-1 Therapy in Hepatocellular Carcinoma by Reducing Direct Phosphorylation and Stability of MYC: CUT-TAG sequencing for MYC in hepatocellular carcinoma cells 16 samples shares phosphorylation, cellular
- GSE146585 Functional genomics assays, including ChIP-seq, ATAC-seq, RNA-seq, GRO-seq, and in situ Hi-C, in the context of replicative senescence 223 samples shares senescence, chip-seq
- GSE269948 Defective RNA processing and ELOA-mediated transcriptional elongation in reversible cellular senescence suggest aging by transcription 162 samples shares senescence, cellular
- GSE310137 Cellular Senescence in the Absence of Galactic Cosmic-Ray Muons 60 samples shares senescence, cellular
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.