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An APE1 Inhibitor Reveals Critical Roles of APE1 Redox Function in Pathogenesis of Chronic Rhinosinusitis and Novel Therapeutics

GSE285228 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/07/01 Platform GPL24247
Summary
We demonstrated that the Apurinic/apyrimidinic endonuclease 1 (APE1) redox inhibitor, C10, effectively blocked Type 2 inflammation and improved chronic rhinosinusitis (CRS) pathology in a mouse model.
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Also filed as BioProject PRJNA1202079 and SRA study SRP553513. Searching any of these in the dataset finder brings you back here.

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