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Transcriptomic profiles of the maternal-fetal interface in wild-type and C1qtnf6-KO mice

GSE285241 Mus musculus (mouse) RNA-seq (gene expression) 24 samples Submitted 2025/11/24 Platform GPL17021
At a glance

RNA-seq (gene expression) · mouse · 24 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Partial embryo loss caused by disruption of the placental hormone CTRP6 coincides with dNK cell abnormalities during pregnancyiScience · 2026
Summary (written by the submitters)
To understand the function of CTRP6 protein during gestation, we performed RNA-seq experiments for the maternal-fetal interface in wild-type and C1qtnf6-KO mice.
Published in
Partial embryo loss caused by disruption of the placental hormone CTRP6 coincides with dNK cell abnormalities during pregnancy
Fan H, Chen X, Du C et al. · iScience 2026 · PMID 41568145 · doi:10.1016/j.isci.2025.114434
This dataset
Open GSE285241 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285241_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1202095 and SRA study SRP553375. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41568145) ↗
Study design
8 conditions, mostly in triplicate
Wild-type, gd10.5, RNA-seq, ×3 C1qtnf6-KO, gd10.5, RNA-seq, ×3 Wild-type, gd14.5, RNA-seq, ×3 C1qtnf6-KO, gd14.5, RNA-seq, ×3 Wild-type, gd16.5, RNA-seq, ×3 C1qtnf6-KO, gd16.5, RNA-seq, ×3 Wild-type, gd19.5, RNA-seq, ×3 C1qtnf6-KO, gd19.5, RNA-seq, ×3

Supports a between-group comparison across 24 samples.

How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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